A risk dyad: periodontitis and COVID-19
Keywords:
COVID-19, SARS-CoV-2, periodontitis, periodontal disease, coronavirus infections, SARS virusAbstract
Background:COVID-19 is a pandemic caused by SARS-CoV-2 virus and its association with periodontitis could have adverse outcomes.
Objective:To evaluate the association between periodontitis and adverse outcomes of COVID-19.
Methodology:A literature review was performed in Google Scholar, SciELO and PubMed Central with the descriptors SARS-CoV-2, COVID-19, periodontitis and periodontal disease consulted in DeCS. Full-text articles in Spanish and English were selected, mainly from peer-reviewed journals.
Results:Periodontitis is significantly associated with COVID-19 severity. Probable mechanisms linking periodontitis with severe COVID-19 are favoring viral replication, inflammation due to immune dysfunction, dysbiosis with superimposed bacterial infection, and the presence of comorbidities. Taking biosecurity and hygiene measures in patient care could favor a more favorable clinical course of COVID-19.
Conclusions:Periodontitis appears to be associated with unfavorable COVID-19 outcomes, emphasizing the importance of stomatologic care of these patients.
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References
1. Ting M, Suzuki JB. SARS-CoV-2: Overview and Its Impact on Oral Health. Biomedicines [Internet]. 2021 [cited 2022 Abr 8];9(11). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615973/pdf/biomedicines-09-01690.pdf
2. Martínez-Pérez ML, Camejo Roviralta L, Sánchez Sánchez RJ. Relación entre la enfermedad periodontal y la cardiopatía isquémica. CCM [Internet]. 2019 [citado 1 Feb 2022];23(4):2101-2121. Disponible en: http://www.revcocmed.sld.cu/index.php/cocmed/article/download/3345/1473
3. Sánchez Rodríguez L, Gómez Porcegué Y, Salas González P, León-Casanova O, Rodríguez-Betancourt M. Enfermedades bucales en pacientes especiales menores de 15 años. Sancti Spíritus. 2016. Gac Méd Espirit [Internet]. 2019 [citado 8 Abr 2022];21(3):62-68. Disponible en: http://scielo.sld.cu/pdf/gme/v21n3/1608-8921-gme-21-03-62.pdf
4. Morón-Araújo M. Stress and Bruxism Due to COVID-19 as Risk Factors in Periodontal Disease. Int J Odontostomat [Internet]. 2021 [cited 2022 Abr 8];15(2):309-314. Available from: http://www.ijodontostomatology.com/wp-content/uploads/2021/05/2021_v15n2_002.pdf
5. Sánchez Artigas R, Sánchez Sánchez R, Sigcho Romero C, Expósito Lara A. Factores de riesgo de enfermedad periodontal. CCM [Internet]. 2021 [citado 8 Abr 2022];25(1). Disponible en: http://revcocmed.sld.cu/index.php/cocmed/article/download/3585/1893
6. Martínez Pérez M, Almaguer Mederos L, Medrano Montero J, Frómeta Delgado D, Cané Rodríguez A. Enfermedad periodontal y factores de riesgo aterotrombótico en pacientes con síndrome coronario agudo. CCM [Internet]. 2020 [citado 9 Abr 2022];24(4):1142-59. Disponible en: http://www.revcocmed.sld.cu/index.php/cocmed/article/download/3577/1578
7. Rusu LC, Ardelean LC, Tigmeanu CV, Matichescu A, Sauciur I, Bratu EA. COVID-19 and Its Repercussions on Oral Health: A Review Medicina [Internet]. 2021 [cited 2022 Abr 8];57(11). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619825/pdf/medicina-57-01189.pdf
8. Gupta S, Mohindra R, Singla M, Khera S, Sahni V, Kanta P, et al. The clinical association between Periodontitis and COVID-19. Clin Oral Invest [Internet]. 2022 [cited 2022 Abr 8];26(2):1361-1374. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390180/pdf/784_2021_Article_4111.pdf
9. Anand PS, Jadhav P, Kamath KP, Kumar SR, Vijayalaxmi S, Anil S. A case-control study on the association between periodontitis and coronavirus disease (COVID-19). J Periodontol [Internet]. 2022 [cited 2022 Feb 1];93:584-590. Available from: https://aap.onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.21-0272
10. Shamsoddin E. Is periodontitis associated with the severity of COVID-19. Evid Based Dent [Internet]. 2021 [cited 2022 Abr 8];22(2):66-68. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226334/pdf/41432_2021_Article_179.pdf
11. Coke CJ, Davison, B, Fields N, Fletcher J, Rollings J, Roberson L, et al. SARS-CoV-2 Infection and OralHealth: Therapeutic Opportunitiesand Challenges. J Clin Med [Internet].2021 [cited 2022 Abr 8];10(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795434/pdf/jcm-10-00156.pdf
12. Herrera D, Serrano J, Roldán S, Sanz M. Is the oral cavity relevant in SARS-CoV-2 pandemic? Clin Oral Investig [Internet]. 2020 [cited 2022 Abr 8];24(8):2925-2930. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309196/pdf/784_2020_Article_3413.pdf
13. Campos Fabri GM. Potential Link between COVID-19 and Periodontitis: Cytokine Storm, Immunosuppression, and Dysbiosis. OHDM [Internet]. 2020 [cited 2022 Abr 8];19(7). Available from: https://www.walshmedicalmedia.com/open-access/potential-link-between-covid19-and-periodontitis-cytokine-storm-immunosuppression-and-dysbiosis.pdf
14. Hajizadeh F, Houshmand B, Ekhlasmandkermani M, Khazaei S, Kheiri A. Cytokine Profiles in Periodontitis and COVID-19. Dent Hypotheses [Internet]. 2021 [cited 2022 Apr 8];12(1):36-8. Available from: https://dentalhypotheses.com/article.asp?issn=2155-8213;year=2021;volume=12;issue=1;spage=36;epage=38;aulast=Hajizadeh;type=3
15. Grigoriadis A, Räisänen IT, Pärnänen P, Tervahartiala T, Sorsa T, Sakellari D. Is There a link between COVID-19 and periodontal disease? A narrative review. Eur J Dent [Internet]. 2022 [cited 2022 Abr 8]. Available from: https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0041-1740223.pdf
16. Siddharthan S, Naing NN, Wan-Arfah N. Periodontal Disease and Covid 19. J Pharm Res Int [Internet]. 2020 [cited 2022 Abr 8];32(32):88-91. Available from: https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-1011778
17. Sukumar K, Tadepalli A. Nexus between COVID-19 and periodontal disease. J Inter Med Res [Internet]. 2021 [cited 2022 Abr 8];49(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989136/pdf/10.1177_03000605211002695.pdf
18. Hernández Vigueras S, Aquino Martínez R. Potencial rol de la periodontitis en la severidad de COVID-19. Revisión. Int J Odontostomat [Internet]. 2021 [citado 6 Abr 2022];15(2):335-341. Disponible en: https://www.scielo.cl/pdf/ijodontos/v15n2/0718-381X-ijodontos-15-02-335.pdf
19. Expósito Lara A, Feria Díaz G, González Benítez S, Miguel-Soca PE. Variantes genéticas del SARS-CoV-2 y sus implicaciones clínicas. Medisan [Internet]. 2021 [citado 7 Abr 2022];25(6):1424-46. Disponible en: http://scielo.sld.cu/pdf/san/v25n6/1029-3019-san-25-06-1424.pdf
20. Imai K, Tanaka H. SARS-CoV-2 infection and significance of oral health management in the era of “the new normal with COVID-19”. Int J Mol Sci [Internet]. 2021 [cited 2022 Abr 8];22(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235682/pdf/ijms-22-06527.pdf
21. Díaz Armas M, Sánchez Artigas R, Matute Respo T, Llumiquinga Achi R. Proteína de la espícula del virus SARS-CoV-2 y su relación con la enzima convertidora de angiotensina-2. Rev Inform Cient [Internet]. 2021 [citado 7 Abr 2022];100(5). Disponible en: http://www.revinfcientifica.sld.cu/index.php/ric/article/download/3633/4890
22. Raghav PK, Kalyanaraman K, Kumar D. Human cell receptors: potential drug targets to combat COVID-19. Amino Acids [Internet]. 2021 [cited 2022 Abr 8];53(6):813-842. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097256/pdf/726_2021_Article_2991.pdf
23. Huang N, Pérez P, Kato T, Mikami Y, Okuda K, Gilmore RC, et al. SARS-CoV-2 infection of the oral cavity and saliva. Nat Med [Internet]. 2021 [cited 2022 Abr 8];27(5):892-903. Available from: https://www.nature.com/articles/s41591-021-01296-8.pdf
24. Nemeth Kohanszky ME, Matus Abásolo CP, Carrasco Soto RR. Manifestaciones orales de la infección por COVID-19. Int J Odontostomat [Internet]. 2020 [citado 8 Abr 2022];14(4):555-560. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240394/pdf/nihms-1716445.pdf
25. Brock M, Bahammam S, Sima C. The Relationships among Periodontitis, Pneumonia and COVID-19. Front Oral Health [Internet]. 2022 [cited 2022 Abr 8];2. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813972/pdf/froh-02-801815.pdf
26. Martínez García M, Hernández Lemus E. Periodontal Inflammation and Systemic Diseases: An Overview Front Physiol [Internet]. 2021 [cited 2022 Abr 8];12. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8578868/pdf/fphys-12-709438.pdf
27. Marouf N, Cai W, Said KN, Daas H, Diab H, Chinta VR, et al. Association between periodontitis and severity of COVID-19 infection: A case control study. J Clin Periodontol [Internet]. 2021 [cited 2022 Abr 8];48(4):483-491. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014679/pdf/JCPE-9999-0.pdf
28. Wang Y, Deng H, Pan Y, Jin L, Hu R, Lu Y, et al. Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study. J Transl Med [Internet]. 2021 [cited 2022 Abr 8];19:528. Available from: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-03198-2
29. Takahashi Y, Watanabe N, Kamio N, Yokoe S, Suzuki R, Sato S, et al. Expression of the SARS-CoV-2 receptor ACE2 and proinflammatory cytokines induced by the periodontopathic bacterium fusobacterium nucleatumin human respiratory epithelial Cells. Int J Mol Sci [Internet]. 2021 [cited 2022 Abr 8];22(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866373/pdf/ijms-22-01352.pdf
30. Qi X, Northridge ME, Hu M, Wu B. Oral health conditions and COVID-19: A systematic review and meta-analysis of the current evidence. Aging Health Res [Internet]. 2022 [cited 2022 Abr 7];2(1). Available from: https://www.sciencedirect.com/science/article/pii/S2667032122000117
31. Lobo LF, Rodrigues C, Trench Pinto L, Lopes AT. Protocolo y atención de infecciones bucales en pacientes COVID-19. Lat Am J Oral Maxillofac Surg [Internet]. 2022 [citado 9 Abr 2022];2(1):12-18. Disponible en: https://www.medigraphic.com/pdfs/lajoms/jom-2022/jom221c.pdf
32. Mancini L, Americo LM, Pizzolante T, Donati R, Marchetti E. Impact of COVID-19 on Periodontitis and Peri-Implantitis: A Narrative Review. Front Oral Health [Internet]. 2022 [cited 2022 Abr 8];3. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866640/pdf/froh-03-822824.pdf
33. Drozdzik A, Drozdzik M. Oral pathology in COVID-19 and SARS-CoV-2 Infection-Molecular Aspects. Int J Mol Sci [Internet]. 2022 [cited 2022 Abr 9];23(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836070/pdf/ijms-23-01431.pdf
34. Şehirli AÖ, Aksoy U, Koca-Ünsal RB, Sayıner S. Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin. Med Hypotheses [Internet]. 2021 [cited 2022 Abr 7];151. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007534/pdf/main.pdf
35. Campisi G, Bizzoca ME, Lo Muzio L. COVID-19 and periodontitis: reflecting on a possible association. Head Face Med [Internet]. 2021 [cited 2022 Abr 8];17(1):16. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110692/pdf/13005_2021_Article_267.pdf
36. Darestani MN, Akbari A, Yaghobee S, Taheri M, Akbari S. COVID-19 pandemic and periodontal practice: The immunological, clinical, and economic points of view. Biomed Res Int [Internet]. 2022 [cited 2022 Abr 9];2022. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8763038/pdf/BMRI2022-3918980.pdf
37. Baltazar Díaz TA, Zamora Pérez AL. Enfermedad periodontal y COVID-19: factores de riesgo y mecanismos compartidos. Rev Mex Periodontol [Internet]. 2021 [citado 9 Abr 2022];12(1-3):12-17. Disponible en: https://www.medigraphic.com/pdfs/periodontologia/mp-2021/mp211d.pdf
38. Falcón-Guerrero BE, Falcón-Pasapera Guido S. Repercusiones en la Cavidad Oral Causadas por la Infección con COVID-19. Int J Odontostomat [Internet]. 2021 [citado 9 Abr 2022];15(1):23-26. Disponible en: https://scielo.conicyt.cl/pdf/ijodontos/v15n1/0718-381X-ijodontos-15-01-23.pdf
39. Bao L, Zhang C, Dong J, Zhao L, Li Y, Sun J. Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection. Front Microbiol [Internet]. 2020 [cited 2022 Abr 8];11. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411080/pdf/fmicb-11-01840.pdf
40. Calderón Eras JN, Jiménez Ramírez AM. Enjuagues bucales efectivos en la COVID-19. Recimundo [Internet]. 2021 [citado 9 Abr 2022];5(2):46-53. Disponible en: https://www.recimundo.com/index.php/es/article/view/1038/1685
41. Sigua Rodríguez EA, Bernal Pérez JL, Lanata Flores AG, Sánchez Romero C, Rodríguez Chessa J, Haidar Ziyad S, et al. COVID-19 y la Odontología: una Revisión de las Recomendaciones y Perspectivas para Latinoamérica. Int J Odontostomat [Internet]. 2020 [citado 7 Abr 2022];14(3):299-309. Disponible en: https://www.recimundo.com/index.php/es/article/download/1038/1685/
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