Cardiovascular disease risk in schizophrenia patients in Sancti Spiritus Province, Cuba

Authors

Keywords:

Schizophrenia and epidemiology, cardiovascular diseases and epidemiology, longitudinal studies, global cardiovascular risk, risk factors, risk tables, schizophrenia

Abstract

Background: Patients with schizophrenia have a higher risk of cardiovascular disease than general population and their life expectancy decreases by 10 to 20 years. The Cuban studies on the prevalence of cardiovascular risk factors in this population are scarce.

Objective: To describe the prevalence of the main risk factors for cardiovascular disease in patients with schizophrenia admitted in hospitals in Sancti Spiritus province, as well as the risk to suffer a coronary event in the next 10 years according to the Framingham risk index.

Methodology: The design was a cross-sectional descriptive observational study in patients with schizophrenia diagnosis admitted in hospitals in Sancti Spiritus province. Inclusion criteria were patients of both sexes, with schizophrenia diagnosis according to CID-10, between 20 and 65 years of age, admitted to the psychiatry service and who did not suffer a serious cardiovascular event. Information was collected on sociodemographic, clinical and laboratory characteristics. The risk of suffering a cardiovascular event was calculated by means of the Framingham formula.

Results: The main cardiovascular risk factors prevalence was smoking (63.1%), hypertension (63.8%), diabetes (22.2%) and overweight (15.9%). The global risk index according to the Framingham formula was 8.2%.

Conclusions: The Framingham risk index for cardiovascular death was considered medium in this population. Smoking, hypertension and diabetes were the most prevalent risk factors.

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Author Biographies

Ederlys Martín García, Hospital Provincial General Camilo Cienfuegos de Sancti Spíritus, Sancti Spíritus

Especialista de primer grado en Psiquiatría y en MGI

Claudia Espinosa Morales, Hospital Provincial General Camilo Cienfuegos de Sancti Spíritus, Sancti Spíritus

Especialista de primer grado en Psiquiatría

Lidivet Martínez Calderón, Hospital Provincial General Camilo Cienfuegos de Sancti Spíritus, Sancti Spíritus

Especialista de primer grado en Psiquiatría y en MGI

Yarielys González Cabrera, Hospital Provincial General Camilo Cienfuegos de Sancti Spíritus, Sancti Spíritus

Especialista de primer grado en Psiquiatría y en MGI

References

1. Plana-Ripoll O, Weye N, Momen NC, Christensen MK, Iburg KM, Laursen TM, et al. Changes Over Time in the Differential Mortality Gap in Individuals With Mental Disorders. JAMA Psychiatry [Internet]. 2020 [cited 2024 Dec 4];77(6):648-50. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC7142807/

2. Nielsen RE, Banner J, Jensen SE. Cardiovascular disease in patients with severe mental illness. Nat Rev Cardiol [Internet]. 2021 [cited 2024 Dec 4];18(2):136-45. Disponible en: https://www.nature.com/articles/s41569-020-00463-7

3. Mensah GA, Wei GS, Sorlie PD, Fine LJ, Rosenberg Y, Kaufmann PG, et al. Decline in Cardiovascular Mortality: Possible Causes and Implications. Circ Res [Internet]. 2017 [cited 2024 Dec 4];120(2):366-80. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC5268076/pdf/nihms839089.pdf.

4. Tanskanen A, Tiihonen J, Taipale H. Mortality in schizophrenia: 30-year nationwide follow-up study. Acta Psychiatr Scand [Internet]. 2018 [cited 2024 Dec 4];138(6):492-9. Disponible en: https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.12913.

5. Ösby U, Westman J, Hällgren J, Gissler M. Mortality trends in cardiovascular causes in schizophrenia, bipolar and unipolar mood disorder in Sweden 1987-2010. Eur J Public Health [Internet]. 2016 [cited 2024 Dec 4];26(5):867-71. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC5054269/pdf/ckv245.pdf.

6. Rødevand L, Steen NE, Elvsåshagen T, Quintana DS, Reponen EJ, Mørch RH, et al. Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatr Scand [Internet]. 2019 [cited 2024 Dec 4];139(4):348-60. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/acps.13008.

7. Cunningham R, Poppe K, Peterson D, Every-Palmer S, Soosay I, Jackson R. Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study. PLoS One [Internet]. 2019 [cited 2024 Dec 4];14(9). Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC6750572/pdf/pone.0221521.pdf.

8. Foguet-Boreu Q, Fernandez San Martin MI, Flores Mateo G, Zabaleta Del Olmo E, Ayerbe García-Morzon L, Perez-Piñar López M, et al. Cardiovascular risk assessment in patients with a severe mental illness: a systematic review and meta-analysis. BMC Psychiatry [Internet]. 2016 [cited 2024 Dec 4];16:141. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC4866037/pdf/12888_2016_Article_833.pdf.

9. Zhao S, Xia H, Mu J, Wang L, Zhu L, Wang A, et al. 10-year CVD risk in Han Chinese mainland patients with schizophrenia. Psychiatry Res [Internet]. 2018 [cited 2024 Dec 4];264:322-6. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0165178117311307?via%3Dihub.

10. Haddad C, Hallit S, Salameh P, Bou-Assi T, Zoghbi M. Coronary heart disease risk in patients with schizophrenia: a Lebanese cross-sectional study. J Comorb [Internet]. 2017 [cited 2024 Dec 4];7(1):79-88. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC5556440/pdf/joc-07-079.pdf.

11. Clerici M, Bartoli F, Carretta D, Crocamo C, Bebbington P, Carrà G. Cardiovascular risk factors among people with severe mental illness in Italy: a cross-sectional comparative study. Gen Hosp Psychiatry [Internet]. 2014 [cited 2024 Dec 4];36(6):698-702. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0163834314002096?via%3Dihub.

12. McCreadie RG. Diet, smoking and cardiovascular risk in people with schizophrenia: descriptive study. Br J Psychiatry [Internet]. 2003 [cited 2024 Dec 4];183:534-9. Disponible en: https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/diet-smoking-and-cardiovascular-risk-in-people-with-schizophrenia/CC1EFBE544997C3DF76E585709143544.

13. Cohn T, Prud'homme D, Streiner D, Kameh H. Remington G. Characterizing coronary heart disease risk in chronic schizophrenia: high prevalence of the metabolic syndrome. Can J Psychiatry [Internet]. 2004 Nov [cited 2024 Dec 4];49(11):753-60. Disponible en: https://doi.org/10.1177/070674370404901106

14. Goff DC, Sullivan LM, McEvoy JP, Meyer JM, Nasrallah HA, Daumit GL, et al. A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls. Schizophr Research [Internet]. 2005 [cited 2024 Dec 4];80(1):45-53. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0920996405003750?via%3Dihub

15. Naderyan Fe'li S, Yassini Ardekani SM, Fallahzadeh H, Dehghani A. Metabolic syndrome and 10-year risk of cardiovascular events among schizophrenia inpatients treated with antipsychotics. Med J Islam Repub Iran [Internet]. 2019 [cited 2024 Dec 4];33:97. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC6825382/pdf/mjiri-33-97.pdf

16. Correll CU, Kane JM, Manu P. Obesity and coronary risk in patients treated with second-generation antipsychotics. Eur Arch Psychiatry Clin Neurosci [Internet]. 2011 [cited 2024 Dec 4];261(6):417-23. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC3125452/pdf/nihms276039.pdf

17. Daumit GL, Goff DC, Meyer JM, Davis VG, Nasrallah HA, McEvoy JP, et al. Antipsychotic effects on estimated 10-year coronary heart disease risk in the CATIE schizophrenia study. Schizophr Res [Internet]. 2008 [cited 2024 Dec 4];105(1-3):175-87. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC2614656/pdf/nihms74869.pdf

Published

2025-06-01

How to Cite

1.
Hernández BM, Martín García E, Espinosa Morales C, Martínez Calderón L, González Cabrera Y, Díaz Armas MT. Cardiovascular disease risk in schizophrenia patients in Sancti Spiritus Province, Cuba. Gac méd espirit [Internet]. 2025 Jun. 1 [cited 2025 Oct. 12];27. Available from: https://revgmespirituana.sld.cu/index.php/gme/article/view/2615

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Section

RESEARCH ARTICLES (Original)